2014 american academy of neurology aano aan patient and provider shared decision making tool on cavernous and arteriovenous malformations five questions for treatment of cavernous and arteriovenous malformations. Established in 1948 the american academy of neurology aan is an international professional association of more than 28000 neurologists and neuroscience professionals dedicated to promoting the highest quality patient centered neurologic care. Objective to find mutations in the recently identified additional exons of the krit1 gene that causes ccm1 a disease characterized by the formation of cerebral cavernous malformations ccm. A cerebral cavernous malformation ccm is a collection of small blood vessels capillaries in the central nervous system cns that is enlarged and irregular in structure. Genetic testing for three genes that are associated with familial cerebral cavernous malformations ccm